There are limitations to using self-sealing screws that you should be aware of when considering them for a particular application. These limitations include:Torque Sensitivity: Self-sealing screws are often sensitive to the torque applied during installation. Over-tightening can damage the sealing element or deform the mating surfaces, leading to leaks. Under-tightening can result in an insufficient seal. Proper torque 

control and following manufacturer guidelines are essential to avoid these issues.

Surface Condition: The effectiveness of self-sealing screws can be compromised if the mating surfaces are not clean, flat, and free from defects. Irregularities or contamination on the mating surfaces can prevent the sealing element from creating a reliable seal.

Reusability: Self-sealing screws may not be suitable for applications that require frequent disassembly and reassembly. The repeated compression and decompression of the sealing element can lead to wear and reduced sealing effectiveness over time.

Temperature Limits: Self-sealing screws may have temperature limitations, especially when it comes to extreme heat or cold. Operating outside the specified temperature range can affect the performance and longevity of the sealing element.

Chemical Compatibility: The choice of sealing material in self-sealing screws must be compatible with the specific fluids or gases in the application. Exposure to incompatible chemicals can lead to degradation of the sealing element, resulting in leaks.

Pressure Ratings: Self-sealing screws are designed for specific pressure ranges. Using them beyond their rated pressure can lead to seal failure, potentially causing leaks and safety hazards.

Vibration and Shock: In high-vibration or shock-prone environments, self-sealing screws may require additional measures, such as thread-locking compounds or secondary locking mechanisms, to prevent loosening and leaks.

Thread Wear: Frequent installation and removal of self-sealing screws can cause wear on the threads, potentially reducing their effectiveness over time. Regular inspection and maintenance may be necessary in such cases.

Material Selection: The choice of materials for self-sealing screws and sealing elements is critical. Incompatibility with the application's environment or fluids can lead to premature failure.Cost: Self-sealing screws may be more expensive than standard screws or other sealing 

methods. It's important to weigh the benefits of leak prevention against the cost when choosing them for an application.

Size Constraints: In some tight or confined spaces, it may be challenging to use self-sealing screws effectively due to their design, including the presence of a sealing element.Installation Skill: Proper installation of self-sealing screws requires skill and attention to detail. Inexperienced or careless installation can result in leaks.

Despite these limitations, self-sealing screws are highly effective in many applications where maintaining a secure and leak-free connection is crucial. It's essential to carefully assess your specific application's requirements and consider these limitations when deciding whether self-sealing screws are the right choice or if alternative sealing methods may be more suitable.